Publication details
Do alpha 5-containing GABA(A) receptors have a role to play in ethanol reward?
| Authors | |
|---|---|
| Year of publication | 2004 |
| Type | Article in Periodical |
| Magazine / Source | Alcoholism: Clinical and Experimental Research |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | ethanol addiction; GABA receptor |
| Description | We tested this hypothesis that GABA(A) receptors containing alpha 5 subunits mediate the rewarding effects of ethanol. Data obtained in a mouse model of ethanol self-administration show, that alpha 5 subunits may not be essential to signaling ethanol reward. Nevertheless, inverse agonists acting at alpha 5-containing receptors reduced ethanol self-administration. |