Publication details

Efficacious but insidious: A retrospective analysis of fludarabine induced myelotoxicity using long term culture initiating cells in 100 follicular lymphoma patients

Authors

JANÍKOVÁ Andrea KOŘÍSTEK Zdeněk VINKLÁRKOVÁ Jaroslava PAVLÍK Tomáš ŠTÍCHA Michal NAVRÁTIL Milan KRÁL Zdeněk VÁŠOVÁ Ingrid MAYER Jiří

Year of publication 2009
Type Article in Periodical
Magazine / Source Experimental Hematology
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords NON-HODGKIN-LYMPHOMA; CHRONIC LYMPHOCYTIC-LEUKEMIA; HEMATOPOIETIC STEM-CELLS; BLOOD PROGENITOR CELLS; ACUTE MYELOID-LEUKEMIA; PREVIOUSLY UNTREATED PATIENTS; IV INDOLENT LYMPHOMA; HIGH-DOSE THERAPY; BONE-MARROW; PHASE-II
Description Fludarabine has been recognized as effective treatment in patients with follicular lymphoma (FL), but can induce myelotoxicity of unknown mechanism. Fludarabine and procarbazine have a dramatic influence, especially on the most immature hematopoietic cells, mirrored in reduced numbers of LTC-IC. This finding is consistent with clinical observations (poor mobilization after fludarabine) and offers an insight into the mechanism of fludarabine-induced myelotoxicity.
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