Publication details

Bilateral quantitative changes of laminin-1 in the spinal nerve roots after unilateral sciatic nerve injury

Authors

DUBOVÝ Petr DAVID Marek KLUSÁKOVÁ Ilona HRADILOVÁ SVÍŽENSKÁ Ivana

Year of publication 2009
Type Article in Proceedings
Conference 9th European Meeting on Glial Cells in Health and Disease
MU Faculty or unit

Faculty of Medicine

Citation
Web
Field Neurology, neurosurgery, neurosciences
Keywords behavioral tests; bilateral reaction of spinal nerve roots; dorsal root; endoneurium; laminin-1; neuropathic pain; peripheral nervous system; unilateral constriction of sciatic nerve; ventral root
Description Changes of laminin-1 (lam-1) were investigated in rat spinal nerve roots after unilateral sciatic nerve ligature. Spinal nerve roots of naive rats displayed lam-1 immunostaining in the basal laminae on outer surface of Schwann cell/axon units with higher brightness in ventral than dorsal roots. Bilateral enhancement of lam-1 immunofluorescence was found in the endoneurium of roots 1 and 3 days after nerve ligature. Compared to rats surviving for 1 or 3 days, apparent bilateral decrease of lam-1 immunofluorescence brightness was observed in both roots 7 days after nerve injury. The lam-1 alterations in ipsi- and contralateral roots were similar, but more distinct in roots of ipsilateral side. The results suggest that quantitative changes of lam-1 are present bilaterally in the endoneurium of spinal nerve roots after unilateral sciatic nerve ligature.
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