Publication details

Predicting non-sentinel lymph node status after positive sentinel biopsy in breast cancer: what model performs the best in a czech population?

Authors

COUFAL Oldřich PAVLÍK Tomáš FABIAN Pavel ET al.

Year of publication 2009
Type Article in Periodical
Magazine / Source PATHOLOGY & ONCOLOGY RESEARCH
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords Breast cancer; Lymphatic metastasis; Nomogram; Prediction; Sentinel lymph node biopsy; Tumor cells; Isolated
Description Several models have previously been proposed to predict the probability of non-sentinel lymph node metastases after a positive sentinel lymph node biopsy in breast cancer. The aim of this study was to assess the accuracy of two previously published nomograms and to develop an alternative model with the best predictive accuracy in a Czech population. In the basic population of 330 SLN-positive Czech patients, the accuracy of the MSKCC and the Stanford nomograms was tested by the area under the receiver operating characteristics curve. A new model was proposed according to the results of multivariate analysis of relevant clinicopathologic variables. The new model was validated in an independent test population from Hungary (383 patients). In the basic population, the previously published nomograms showed only limited accuracy. The developed MOU nomogram proved more suitable for the basic population, such as for another independent population from a mid-European country.

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