Publication details

Genetic Interaction Between Lrp6 and Wnt5a During Mouse Development

Authors

ANDERSSON Emma BRYJOVÁ Lenka BIRIS Kristin YAMAGUCHI Terry ARENAS Ernest BRYJA Vítězslav

Year of publication 2010
Type Article in Periodical
Magazine / Source Developmental dynamics
MU Faculty or unit

Faculty of Science

Citation
Field Genetics and molecular biology
Keywords Wnt5a; Lrp6; somitogenesis; development
Description Lrp6 is generally described as a receptor required for signal transduction in the Wnt/b-catenin pathway. Wnt5a, however, is a Wnt ligand which usually does not activate Wnt/b-catenin but rather activates non-canonical Wnt signaling. Here we describe phenotypes found in Wnt5a/Lrp6 compound mutant mice, including a worsening of individual Wnt5a or Lrp6 loss of function phenotypes. Lrp6 haploinsufficiency in a Wnt5a-/- background caused spina bifida and exacerbated posterior truncation.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.

More info