Publication details
In silico mutagenesis and docking study of RSL lectin
| Title in English | In silico mutagenesis and docking study of RSL lectin, Material Structure in Chemistry, Biology, Physics and Technology vol. 17, no 1a, 2010, page-b45. 2010 |
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| Year of publication | 2010 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | The gram-negative bacterium Ralstonia solanacearum produces a potent L-fucose binding lectin (RSL). This work is focused on in silico mutagenesis, docking of fucose and fucosylated oligosaccharides in RSL lectin. Binding energy pattern of various saccharides was investigated by a series of docking simulations. Docking experiments were performed using the software AutoDock 3, AutoDock Vina, DOCK v.6.2 and ICM Dock. Performance of various docking programs will be discussed with respect to binding energy of those saccharides measured from SPR experiment. |
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