Publication details

Věkem podmíněná makulární degenerace, souborný referát

Title in English Age related macular degeneration, comprehensive review


Year of publication 2004
Type Article in Proceedings
Conference Sborník 5. Vejdovského olomouckého vědeckého dne
MU Faculty or unit

Faculty of Medicine

Field ORL, ophthalmology, stomatology
Keywords age related macular degeneration; choriodeal neovascular membrane; fluorescence angiography; optical coherence tomography
Description Age-related macular degeneration (AMD) is the most common cause of severe vision loss in developed countries in the population over 65 years of age. In a study of aetiopathogenesis of AMD occurred in the last 10 years a significant shift. It was found that the influence of age is to reduce the number of cells of the retinal pigment epithelium (PE). This leads to a reduction in the number of melanosomes, which have a protective effect against the toxic effects of blue light in particular. Due to the increasing age is the accumulation of lipofuscin, protein aging, the activation of free oxygen radicals leads to accelerate the process of apoptosis (natural cell death).

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