Publication details

Negative regulation of Wnt signaling mediated by CK1- phosphorylated Dishevelled via Ror2

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WITTE Florian BERNATÍK Ondřej KIRCHNER Katharina MAŠEK Jan MAHL Annika KREJČÍ Pavel MUNDLOS Stefan SCHAMBONY Alexandra BRYJA Vítězslav STRICKER Sigmar

Year of publication 2010
Type Article in Periodical
Magazine / Source FASEB JOURNAL
MU Faculty or unit

Faculty of Science

Field Genetics and molecular biology
Keywords Wnt/beta-catenin signaling; casein kinase; Ror2
Description Dishevelled (Dvl) is a multifunctional effector of different Wnt cascades. We provide evidence that Dvl phosphorylated by casein kinase 1 epsilon can bind atypical receptor kinase Ror2. We show that CK1-phosphorylated Dvl induced by both canonical and non-canonical Wnt ligands triggers negative feedback regulation in a Ror2-dependent manner.
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