Publication details

Changes in hemocoagulation in acute stroke patients after one-hour sono-thrombolysis using a diagnostic probe.

Authors

SKOLOUDIK D. SANÁK Daniel FADRNÁ Táňa KANOVSKÝ Petr ROUBEC Martin BAR Michal ZAPLETAL Ondřej BLATNÝ Jan LANGOVÁ Kateřina BARDON Petr

Year of publication 2010
Type Article in Periodical
Magazine / Source Ultrasound In Medicine And Biology
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1016/j.ultrasmedbio.2010.04.010
Field Traumatology and orthopaedic surgery
Keywords Ultrasound monitoring; Sono-thrombolysis; Stroke; Hemocoagulation; Fibrinolytic system; Transcranial Doppler
Description The aim was to monitor the changes in hemocoagulation parameters in acute ischemic stroke (AIS) patients after sono-thrombolysis of the occluded middle cerebral artery using a duplex transcranial probe with 2.0-MHz frequency in Doppler mode. Sixteen AIS patients indicated for intravenous thrombolysis (IVT) (8 males; mean age 68.3 +/- 7.1 y) and 16 AIS patients contraindicated for IVT (11 males; mean age 67.9 +/- 7.9 y) were randomized for sono-thrombolysis (8 + 8 patients) or standard treatment (control group) (8 + 8 patients). The significant decrease of plasminogen activator inhibitor-1, plasminogen and alpha-2-antiplasmin activity by a mean of 60, 32 and 24%, respectively, and the increase of tissue plasminogen activator by a mean of 56% was found after sono-thrombolysis when compared with control group (p < 0.0125); these changes were more evident in patients treated with a combination of sono-thrombolysis and IVT (79, 38, 50 and 82%, respectively) than in patients treated by sono-thrombolysis alone (34, 13, 17 and 30%, respectively). The aim was to monitor the changes in hemocoagulation parameters in acute ischemic stroke (AIS) patients after sono-thrombolysis of the occluded middle cerebral artery using a duplex transcranial probe with 2.0-MHz frequency in Doppler mode.

You are running an old browser version. We recommend updating your browser to its latest version.

More info