Aripiprazole does not influence methamphetamine I.V. self-administration in rats

• Authors: KUČEROVÁ Jana; PISTOVČÁKOVÁ Jana; VRŠKOVÁ Dagmar; ŠULCOVÁ Alexandra
• Year of publication: 2010
• Type: Article in Periodical
• Magazine / Source: Activitas Nervosa Superior Rediviva
• MU Faculty or unit: Faculty of Medicine
• Field: Pharmacology and pharmaceutical chemistry
• Keywords: methamphetamine; aripiprazole; IV Self-administration; behavioural sensitization; Wistar rats
• Description: The behavioural sensitization to methamphetamine (MET) induced by 14 day intraperitoneal administration of methamphetaminedecreased the number of the drug doses self-administered per session. This finding might result from increasing efficacy of the drug after sensitization caused by repeated MET intermittent administration. However, aripiprazole did not influence MET intake neither in the behaviourally methamphetamine sensitized nor in the non-sensitized rats.

Related projects

• The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.