Publication details
The effect of lipid peroxidation products on reactive oxygen species formation and nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages
| Authors | |
|---|---|
| Year of publication | 2011 |
| Type | Article in Periodical |
| Magazine / Source | Toxicology in Vitro |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TCP-516MRBX-1&_user=1409883&_coverDate=02%2F28%2F2011&_rdoc=1&_fmt=high&_orig=gateway&_origin=gateway&_sort=d&_docanchor=&view=c&_acct=C000052629&_version=1&_urlVersion=0&_userid=1409883&md5=2d0f |
| Field | Immunology |
| Keywords | Lipid peroxidation; Acrolein; 4-Hydroxynonenal; Malondialdehyde; Reactive oxygen species; Reactive nitrogen species |
| Description | The aim of the present study was to investigate the effects of lipid peroxidation products (LPPs) – acrolein, 4-hydroxynonenal, and malondialdehyde – on ROS and NO production in RAW 264.7 macrophages. Our study shows that the cytotoxic action of acrolein and 4-hydroxynonenal works in a dose- and timedependent manner. Moreover, LPPs can inhibit ROS and NO production partially independently of their toxic effect. Changes in enzymatic pathways and NO scavenging properties are included in the downregulation of reactive species formation. |