Methamphetamine does not influence the metabolic activity of CYP 1A2, 2C6 and 2D2 isoenzymes in the animal study

• Authors: ZENDULKA Ondřej; JUŘICA Jan; SABOVÁ Michaela; ŠULCOVÁ Alexandra
• Year of publication: 2010
• Type: Article in Periodical
• Magazine / Source: Activitas Nervosa Superior Rediviva
• MU Faculty or unit: Faculty of Medicine
• web: http://www.rediviva.sav.sk/52i4/269.pdf
• Field: Pharmacology and pharmaceutical chemistry
• Keywords: methamphetamine; cytochrome P450; isolated perfused rat liver
• Description: Graduating doses (2,5-10 mg kg day)of methamphetamine administered for 10 days did not significantly influenced the metabolic activity of hepatic CYP450 1A2, 2C6 and 2D2.

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