Publication details

Kryoglobulinémie a její rizika při laboratorním vyšetřování-kazuistika

Title in English Cryoglobulinemia and its risks on laboratory examination - case report
Authors

ČERMÁKOVÁ Zdeňka GOTTWALDOVÁ Jana

Year of publication 2009
Type Article in Periodical
Magazine / Source Klinická biochemie a metabolismus
MU Faculty or unit

Faculty of Medicine

Citation
Web
Field Biochemistry
Keywords cryoglobulinemia,cryoprecipitate,protein electrophoresis, monoclonal imunoglobulin
Description Cryoglobulinemia is characterized by presence of abnormal plasma protein. This protein reversibly precipitates upon cooling and causes variety of peripheral vascular manifestations. Cryoglobulins are found in association with broad spectrum of diseases. We reported case suspected of cryoglobulinemia. Blood specimens were drawn, transported and investigated at temperature 37 degrees Celsius. Serum assigned strong cryoprecipitate properties.Unexpectedly there were no abnormalities on electrophoresis of serum proteins.Protein electrophoresis was made once more after incubation with mercaptoethanol and in this case we could see peak of monoclonal protein there.

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