Solution Study of Metal Complexes with Macrocyclic Ligands having Carboxylate and Phosphonate Pendant Arms

• Authors: LUBAL Přemysl; CAMPELLO MPC; ŠEVČÍK Radek; VANĚK Jakub; ŠEVČÍKOVÁ Romana; HERMANN Petr; SANTOS Isabel; MARTINEZ Manuel
• Year of publication: 2011
• Type: Conference abstract
• MU Faculty or unit: Central European Institute of Technology
• Description: Ln(III) and Cu(II) complexes are utilized in medicine and preclinical research as magnetic resonance, optical or nuclear probes for diagnostics and/or for cancer treatment. For biomedical applications, such complexes should exhibit a high thermodynamic stability as well as kinetic inertness under physiological conditions. Thus, knowledge of their thermodynamic/kinetic properties (e.g. dissociation rate constants for an estimation of kinetic inertness) is important to evaluate their use in these applications. Here, thermodynamic and kinetic properties of Cu(II), Ce(III) and Eu(III) complexes with macrocyclic cyclen-based ligands where acetate pendant arms were substituted by phosphonates (H4dota, H5do3ap, trans-H6do2a2p, H7doa3p, H8dotp) [1, 2] are presented. The substitution of acetate functional group(s) by phosphonate(s) has a definite impact on the kinetic inertness of the mentioned metal complexes and, therefore, this fact should be taken for possible in vivo application as BFC’s.

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