prof. RNDr. Zbyněk Prokop, Ph.D.

Head, Kinetics and Microfluidics


Office: bud. A13/232
Kamenice 753/5
625 00 Brno

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Phone: +420 549 49 6667
E‑mail:
CV

Curriculum Vitae

Person Identification
  • Prof. Zbynek Prokop, Ph.D.
    born May 07, 1974 in Brno, Czech Republic
Affiliation and Address
  • Loschmidt Laboratories, Institute of Experimental Biology and RECETOX, Faculty of Science, Masaryk University, Kamenice 5/A13, 625 00 Brno,Czech Republic
Professor
  • Head, Laboratory of Kinetics and Microfluidics
Education and Academic Qualifications
  • 2011: Prof., Environmental Chemistry, Masaryk University, Brno, Czech Republic
  • 2011: Assoc. Prof., Environmental Chemistry, Masaryk University, Brno, Czech Republic
  • 2001: Ph.D., Environmental Chemistry, Masaryk University, Brno, Czech Republic
Employment Summary
  • 2000 – present: Faculty of Science, Masaryk University, Brno, Czech Republic
  • 2013 – present: International Clinical Research Center, St. Anne's University Hospital Brno
Pedagogical Activities
  • Bi7430 Molecular biotechnology
  • Bi7430c Molecular biotechnology - practice
  • Bi5111, Bi6009, Bi7623, Bi8624, Bi9625, Bi0626 Seminar of microbiology
  • Bi9280 Summer school of protein engineering
  • Bi7893 Seminar of Loschmidt laboratories
  • Bi7894 Seminar of research teams in Loschmidt laboratories
Research Projects
  • Enzyme Mechanism and Kinetics
  • Enzyme-Based Technologies
  • Protein Engineering
  • Microfluidics
Academical Stays
  • 4-5/2016: Technische Universität Wien, Austria
  • 7-9/2014: ETH Zurich, Switzerland (EU-ERA Grant)
  • 2/2012: University of Cambridge, United Kingdom
  • 8/2011: University of Cambridge, United Kingdom
  • 1/2010: Eötvös University, Hungary (EMBO Networking Grant)
  • 2/2005: University of Hannover, Germany (NATO Collaborative Linkage Grant)
  • 11/2004: EMBL Heidelberg, Germany (EMBO Networking Grant)
  • 2-4/2004: University of Groningen, The Netherlands (EMBO Fellowship)
  • 1-2/2002: University of Groningen, The Netherlands (NATO Science Fellowship)
  • 10-11/2001: University of Groningen, The Netherlands (FEMS Fellowship)
  • 3-5/1999: University of Ghent, Belgium (EU Socrates Student Exchange Program)
International Courses
  • 2019: 13th New enzymology kinetics workshop, Brno, Czech Republic
  • 2017: EMBO Course of Transient Kinetics, University of Kent, United Kingdom
  • 2016: Time-resolved Fluorescence Spectroscopy, Berlin, Germany
  • 2016: Time-resolved microscopy and correlation spectroscopy, Berlin, Germany
  • 2014: Course on modern enzyme kinetics, University of Texas, Austin, USA
  • 2011: EMBO Laboratory Management Course, DE-Leimen, Germany
  • 2008: EMBO Course of Transient Kinetic Methods, University of Kent, United Kingdom
  • 2006: Advanced Course on Biocatalysis, Technical University of Delft, The Netherlands
  • 2002: Course on CD-Spectrometry, University of Warwick, United Kingdom
  • 2001: Course on CD-Spectrometry, University of Budapest, Hungary
Membership in Scientific Organizations
  • Czech Society or Biochemistry and Molecular Biology
  • Czech Chemical Society
  • Czechoslovak Society of Microbiology
  • Czech Society for Analytical Cytology
Appreciation by Scientific Community
  • 2015: The best technology paper in 2014, Environmental Science & Technology, ACS
  • 2015: Werner von Siemens Award for Excellence in Innovation, Siemens
  • 2014: The Best Academy/Industry Collaboration of The Year, 2nd Price, American Chamber of Commerce and Czech Association for Foreign Investment
  • 2008: J. V. Kostir Prize for Biochemistry, Czech Society of Biochememistry and Molecular Biology
  • 2005: Alfred Bader Prize for Bioorganic Chemistry, Czech Chemical Society
  • 2005: Excellence in Inovation Award of the Rector of Masaryk University
  • 2002: Award for the Young Czech and Slovak Microbiologist of the Year, Czechoslovak Microbiological Society
  • 2000: First place, Student Poster Competition, 5-th Internation Symposium on Environmental Contamination in Central and Eastern Europe
Selected Publications
  • MAZURENKO, Stanislav, Zbyněk PROKOP a Jiří DAMBORSKÝ. Machine Learning in Enzyme Engineering. ACS Catalysis, WASHINGTON: AMER CHEMICAL SOC, 2020, roč. 10, č. 2, s. 1210-1223. ISSN 2155-5435. doi:10.1021/acscatal.9b04321. URL info
  • JINDAL, Garima, Kateřina SLÁNSKÁ, Veselin KOLEV, Jiří DAMBORSKÝ, Zbyněk PROKOP a Arieh WARSHEL. Exploring the challenges of computational enzyme design by rebuilding the active site of a dehalogenase. Proceedings of the National Academy of Sciences of the United States of America, WASHINGTON: NATL ACAD SCIENCES, 2019, roč. 116, č. 2, s. 389-394. ISSN 0027-8424. doi:10.1073/pnas.1804979115. URL info
  • KOKKONEN, Piia Pauliina, J. SYKORA, Zbyněk PROKOP, A. GHOSE, David BEDNÁŘ, M. AMARO, Koen BEERENS, Šárka NEVOLOVÁ, Michaela SLÁNSKÁ, Jan BREZOVSKÝ, Jiří DAMBORSKÝ a M. HOF. Molecular Gating of an Engineered Enzyme Captured in Real Time. Journal of the American Chemical Society, Washington: American Chemical Society, 2018, roč. 140, č. 51, s. 17999-18008. ISSN 0002-7863. doi:10.1021/jacs.8b09848. URL info
  • MAZURENKO, Stanislav, Antonín KUNKA, Koen BEERENS, Christopher M. JOHNSON, Jiří DAMBORSKÝ a Zbyněk PROKOP. Exploration of Protein Unfolding by Modelling Calorimetry Data from Reheating. Scientific Reports, London: NATURE PUBLISHING GROUP, 2017, roč. 7, November, s. nestránkováno. ISSN 2045-2322. doi:10.1038/s41598-017-16360-y. URL info
  • GIELEN, Fabrice, Tomáš BURYŠKA, Liisa VAN VLIET, Maren BUTZ, Jiří DAMBORSKÝ, Zbyněk PROKOP a Florian HOLLFELDER. Interfacing Microwells with Nanoliter Compartments: A Sampler Generating High-Resolution Concentration Gradients for Quantitative Biochemical Analyses in Droplets. Analytical Chemistry, 2015, roč. 87, č. 1, s. 624-632. ISSN 0003-2700. doi:10.1021/ac503336g. URL info
  • DVOŘÁK, Pavel, Šárka BIDMANOVÁ, Jiří DAMBORSKÝ a Zbyněk PROKOP. Immobilized Synthetic Pathway for Biodegradation of Toxic Recalcitrant Pollutant 1,2,3-Trichloropropane. Environmental Science & Technology, 2014, roč. 48, č. 12, s. 6859-6866. ISSN 0013-936X. doi:10.1021/es500396r. info
  • SYKORA, J., Jan BREZOVSKÝ, Táňa KOUDELÁKOVÁ, M. LAHODA, Andrea FOŘTOVÁ, T. CHERNOVETS, Radka CHALOUPKOVÁ, Veronika ŠTĚPÁNKOVÁ, Zbyněk PROKOP, I. KUTA SMATANOVA, M. HOF a Jiří DAMBORSKÝ. Dynamics and Hydration Explain Failed Functional Transformation in Dehalogenase Design. Nature Chemical Biology, 2014, roč. 10, č. 6, s. 428-430. ISSN 1552-4450. info
  • PROKOP, Zbyněk, Yukari SATO, Jan BREZOVSKÝ, Tomáš MOZGA, Radka CHALOUPKOVÁ, Táňa KOUDELÁKOVÁ, Petr JEŘÁBEK, Veronika ŠTĚPÁNKOVÁ, Rio NATSUME, J.G.E. LEEWEN, D,B. JANSSEN, J. FLORIAN, Yuji NAGATA, T. SENDA a Jiří DAMBORSKÝ. Enantioselectivity of Haloalkane Dehalogenases and its Modulation by Surface Loop Engineering. Angewandte Chemie International Edition, Wiley-VCH Verlag GmbH & Co. KGaA, Weinhe, 2010, roč. 49, č. 35, s. 6111-6115. ISSN 1433-7851. URL info
  • PROKOP, Zbyněk, Andrea FOŘTOVÁ, Radka CHALOUPKOVÁ, Martina PAVLOVÁ, Eva CHOVANCOVÁ, Jan BREZOVSKÝ, Martin KLVAŇA, Táňa KOUDELÁKOVÁ, Tomáš MOZGA, Antonín PAVELKA, Pavel DVOŘÁK, Monika STRAKOVÁ a Jiří DAMBORSKÝ. Engineering of Biocatalysts by Modification of Access Tunnels. In Novel Enzymes. 2010. info
  • PROKOP, Zbyněk, Marta MONINCOVÁ, Radka CHALOUPKOVÁ, Martin KLVAŇA, Yuji NAGATA, Dick B. JANSSEN a Jiří DAMBORSKÝ. Catalytic mechanism of the haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT26. Journal of Biological Chemistry, 2003, roč. 278, č. 46, s. 45094-45100. ISSN 0021-9258. URL info

2020/06/18