Project information

In vitro models for study of endocrine disruption - effects of traditional and new types of persistent organic pollutants

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Project Identification
Project Period
1/2005 - 12/2007
Investor / Pogramme / Project type
Czech Science Foundation
MU Faculty or unit
Faculty of Science
endocrine disruption, estrogenity, androgenity, RAR/RXR, steroidogenesis, receptors, POPs

Project proposes development and validation of a system of in vitro tests for detection of endocrine disruption potential of environmental contaminants that is unique in the Czech Republic. The tests will enable to study interactions of xenobiotics withr egulation mechanisms on the level of receptors (estrogen, androgen, glucocorticoid, retinoid) and steroidogenesis. The methods can be used to study important pollutants, as well as agrochemicals, pharmaceuticals or complex mixtures from environmentalsamp les. The project will bring new information on potential of persistent organic pollutants (POPs), which significantly contribute to environmental pollution in the Czech Republic, to affect the endocrine system. The project will be focused on fillinggaps in information about commonly studied POPs and on testing new priority POPs. The results will complement ecotoxicological characteristics of studied compounds and contribute to prediction of risks related to contamination.


Total number of publications: 38

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