Project information

Molecular basis of aberrant splicing of CFTR exon 9

Project Identification
3014
Project Period
1/2015 - 12/2020
Investor / Pogramme / Project type
EMBO (European Molecular Biology Organization)
MU Faculty or unit
Central European Institute of Technology

Alternative splicing of pre-mRNAs is tightly regulated and any imbalance can change the outcome of gene expression which often leads to disease. Despite the importance of alternative splicing regulation our knowledge at the molecular level is still in its infancy hampering development of effective therapies. We plan to study the regulatory RNA-protein interaction network leading to skipping of CFTR exon 9 associated with severe forms of cystic fibrosis. Structure determination of regulatory complexes by NMR spectroscopy in combination with biochemical and functional in vivo studies will be used to deepen our molecular understanding of the regulatory networks governing the proper assembly of mRNAs. With this, we want to lay a rational, structure-function-based foundation for novel approaches to cure diseases.

Publications

Total number of publications: 1