Project information
Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
- Project Identification
- MSM0021622430
- Project Period
- 1/2007 - 12/2013
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Other MU Faculty/Unit
- Faculty of Science
- Other MU Faculty/Unit
- Faculty of Informatics
- Other MU Faculty/Unit
- Central European Institute of Technology
- Keywords
- embryonic stem cells
The goal of this project will be a) to profit from availability of unique cellular resources - mouse and human embryonic stem cells and normal and malignant hematopoietic stem/progenitor cells, b) to effectively employ a wide variety of current and complementary methodologies available to the consortium, and c) to exploit a proven/certified expertise in working with various living systems that span from in vitro cultured cells, through animal models to oncohematological patients. All this together will represent a powerful experimental platform aimed at addressing a nature of molecules and molecular mechanisms underlaying phenomena that are common to both normal and cancer stem cells, mainly their ability to self-renew and to enter differentiation pathways. Integral part of this general goal is to implement multifaceted analytical approach that will cover studies of gene expression at both mRNA and protein levels, evaluating function of extra and intracellular signaling pathways, and analyzing biological properties of cells in vitro and in vivo. Expected outcome will be not only understanding but also a definition of molecules and/or molecular pathways to be tested as therapeutic targets, and cellular models that will make such testing feasible.
Publications
Total number of publications: 358
2009
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Successful treatment of steroid-refractory hepatitic variant of liver graft-vs host disease with pulse cyclophosphamide
Experimental Hematology, year: 2009, volume: 37, edition: 6
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The in vitro proliferation potential and proportion of CD133+ versus CD34+ hematopoietic stem cells
Experimental Hematology, Volume 37, Number 9, year: 2009
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The persistence of t(14;18)-bearing cells in lymph nodes of patients with follicular lymphoma in complete remission: the evidence for ´a lymphoma stem cell´
Leukemia and Lymphoma, year: 2009, volume: 50, edition: 7
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Wnt/beta-Catenin Signaling Blockade Promotes Neuronal Induction and Dopaminergic Differentiation in Embryonic Stem Cells
Stem Cells, year: 2009, volume: 27, edition: 12
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Wnt5a is required for endothelial differentiation of embryonic stem cells and vascularization via pathways involving both Wnt/beta-catenin and protein kinase C alfa
Circulation Research, year: 2009, volume: 104, edition: 3
2008
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A novel interaction between fibroblast growth factor receptor 3 and the p85 subunit of phosphoinositide 3-kinase: activation-dependent regulation of ERK by p85 in multiple myeloma cells
HUMAN MOLECULAR GENETICS, year: 2008, volume: 18, edition: 11
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A novel MGB probe-based assessment of minimal residual disease in patients with acute myeloid leukemia carrying NPMI (nucleophosmin) exon 12 mutations
Year: 2008, type: Conference abstract
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An atypical junction of BCR-ABL gene as molelcular marker for quantitative monitoring of minimal residual disease in patients with chronic myeloid leukemia (CML)
Year: 2008, type: Conference abstract
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Analýza efektu inhibice cyklin dependentních kináz na diferenciaci lidských embyonálních kmenových buněk
Year: 2008, type: Conference abstract
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Beta-Arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways
EMBO REPORTS, year: 2008, volume: 9, edition: 12