Genetically distinct groups of syphilis-causing strains: do they differ during experimental infection?
- Project Identification
- Project Period
- 1/2017 - 7/2018
- Investor / Pogramme / Project type
- Czech Science Foundation
- MU Faculty or unit
- Faculty of Medicine
Treponema pallidum ssp. pallidum (TPA) is a causative agent of syphilis. The recent expansion of treponemal genomic data revealed that TPA reference strains form two genetically distinct groups – the Nichols-like and SS14-like strains. No information on differences in their pathogenic potential or virulence properties is available. Since these two groups represent two genetically distant lineages, differences in virulence properties can be also expected. The differences in virulence potential of these subgroups will be studied during experimental infection of syphilis-causing treponemes in vivo in the rabbit model.
Total number of publications: 5