Informace o projektu
Genetically distinct groups of syphilis-causing strains: do they differ during experimental infection?
- Kód projektu
- GJ17-25589Y
- Období řešení
- 1/2017 - 7/2018
- Investor / Programový rámec / typ projektu
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Grantová agentura ČR
- Juniorské granty
- Fakulta / Pracoviště MU
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Lékařská fakulta
- Mgr. Michal Strouhal, Ph.D.
- Mgr. Linda Grillová, Ph.D.
- Mgr. Jan Haviernik, Ph.D.
Treponema pallidum ssp. pallidum (TPA) is a causative agent of syphilis. The recent expansion of treponemal genomic data revealed that TPA reference strains form two genetically distinct groups – the Nichols-like and SS14-like strains. No information on differences in their pathogenic potential or virulence properties is available. Since these two groups represent two genetically distant lineages, differences in virulence properties can be also expected. The differences in virulence potential of these subgroups will be studied during experimental infection of syphilis-causing treponemes in vivo in the rabbit model.
Publikace
Počet publikací: 5
2020
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Whole genome sequence of the Treponema pallidum subsp. endemicum strain Iraq B: A subpopulation of bejel treponemes contains full-length tprF and tprG genes similar to those present in T. p. subsp. pertenue strains
Plos One, rok: 2020, ročník: 15, vydání: 4, DOI
2018
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Complete genome sequences of two strains of Treponema pallidum subsp pertenue from Indonesia: Modular structure of several treponemal genes
PLoS neglected tropical diseases, rok: 2018, ročník: 12, vydání: 10, DOI
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Genetics of human and animal uncultivable treponemal pathogens
Infection, Genetics and Evolution, rok: 2018, ročník: 61, vydání: JUL 2018, DOI
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Molecular characterization of Treponema pallidum subsp pallidum in Switzerland and France with a new multilocus sequence typing scheme
Plos one, rok: 2018, ročník: 13, vydání: 7, DOI
2017
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Complete genome sequences of two strains of Treponema pallidum subsp. pertenue from Ghana, Africa: Identical genome sequences in samples isolated more than 7 years apart
PLOS Neglected Tropical Diseases, rok: 2017, ročník: 11, vydání: 9, DOI