Personalized Medicine – Diagnostics and Therapy
- Project Identification
- TN01000013
- Project Period
- 1/2019 - 12/2022
- Investor / Pogramme / Project type
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Technology Agency of the Czech Republic
- National competence centers 1
- MU Faculty or unit
- Central European Institute of Technology
- Cooperating Organization
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Institute of Physiology of the ASCR, v. v. i.
Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
- Responsible person Doc. Ing. Martin Fusek, CSc.
Palacký University, Olomouc
Technical University Ostrava
Prague Institute of Chemical Technology
University Hospital Olomouc
St. Anne's University Hospital Brno
University Hospital Brno-Bohunice
General Teaching Hospital Praha
IntellMed, s.r.o.
Institute of Applied Biotechnologies a.s.
APIGENEX s.r.o.
Tilia Genomic a.s.
Centrum PerMed je zaměřeno na aplikovaný výzkum v oblasti diagnostiky a terapie zřídkavých a geneticky podmíněných onemocnění. Cílem práce centra je vyvinout personalizované diagnostické metody a zároveň látky - kandidáty léčiv, které budou pomáhat specifickým skupinám pacientů. Přístup je založen na interdisciplinaritě kombinací chemie a biologie, genetiky a bioinformatiky. Celý výzkum je rozdělen do pracovních aktivit jako je validace vhodných molekulárních cílů, biologická chemie, preklinický vývoj, identifikace biomarkerů a DNA analýzu. Výsledky centra PerMed budou komercionalizovány jednak prodejem licencí a jednak vznikem spin-off společností.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 19
2022
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Extended Mechanism of the Plasminogen Activator Staphylokinase Revealed by Global Kinetic Analysis: 1000-fold Higher Catalytic Activity than That of Clinically Used Alteplase
ACS Catalysis, year: 2022, volume: 12, edition: 7, DOI
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Fast approximative methods for study of ligand transport and rational design of improved enzymes for biotechnologies
Biotechnology Advances, year: 2022, volume: 60, edition: November, DOI
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Fractional Flow Reserve Versus Instantaneous Wave-Free Ratio in Assessment of Lesion Hemodynamic Significance and Explanation of their Discrepancies. International, Multicenter and Prospective Trial: The FiGARO Study
Journal of the American Heart Association, year: 2022, volume: 11, edition: 9, DOI
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Increased occurrence of Treponema spp. and double-species infections in patients with Alzheimer's disease
Science of the Total Environment, year: 2022, volume: 844, edition: October 2022, DOI
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New-Generation Heterocyclic Bis-Pentamethinium Salts as Potential Cytostatic Drugs with Dual IL-6R and Mitochondria-Targeting Activity
Pharmaceutics, year: 2022, volume: 14, edition: 8, DOI
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Non-psychotropic cannabinoids as inhibitors of TET1 protein
Bioorganic Chemistry, year: 2022, volume: 124, edition: July 2022, DOI
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Pentamethinium salts suppress key metastatic processes by regulating mitochondrial function and inhibiting dihydroorotate dehydrogenase respiration
Biomedicine & Pharmacotherapy, year: 2022, volume: 154, edition: October 2022, DOI
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Very rare near-haploid acute lymphoblastic leukemia resistant to immunotherapy and CAR-T therapy in 19-year-old male patient
CLINICAL CASE REPORTS, year: 2022, volume: 10, edition: 3, DOI
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Virtual screening of potential anticancer drugs based on microbial products
Seminars in Cancer Biology, year: 2022, volume: 86, edition: November 2022, DOI
2021
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Computational design of enzymes for biotechnological applications
Biotechnology Advances, year: 2021, volume: 47, edition: March–April, DOI