Personalized Medicine – Diagnostics and Therapy
- Project Identification
- TN01000013
- Project Period
- 1/2019 - 12/2022
- Investor / Pogramme / Project type
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Technology Agency of the Czech Republic
- National competence centers 1
- MU Faculty or unit
- Central European Institute of Technology
- Cooperating Organization
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Institute of Physiology of the ASCR, v. v. i.
Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
- Responsible person Doc. Ing. Martin Fusek, CSc.
Palacký University, Olomouc
Technical University Ostrava
Prague Institute of Chemical Technology
University Hospital Olomouc
St. Anne's University Hospital Brno
University Hospital Brno-Bohunice
General Teaching Hospital Praha
IntellMed, s.r.o.
Institute of Applied Biotechnologies a.s.
APIGENEX s.r.o.
Tilia Genomic a.s.
Centrum PerMed je zaměřeno na aplikovaný výzkum v oblasti diagnostiky a terapie zřídkavých a geneticky podmíněných onemocnění. Cílem práce centra je vyvinout personalizované diagnostické metody a zároveň látky - kandidáty léčiv, které budou pomáhat specifickým skupinám pacientů. Přístup je založen na interdisciplinaritě kombinací chemie a biologie, genetiky a bioinformatiky. Celý výzkum je rozdělen do pracovních aktivit jako je validace vhodných molekulárních cílů, biologická chemie, preklinický vývoj, identifikace biomarkerů a DNA analýzu. Výsledky centra PerMed budou komercionalizovány jednak prodejem licencí a jednak vznikem spin-off společností.
Publications
Total number of publications: 13
2022
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Extended Mechanism of the Plasminogen Activator Staphylokinase Revealed by Global Kinetic Analysis: 1000-fold Higher Catalytic Activity than That of Clinically Used Alteplase
ACS Catalysis, year: 2022, volume: 12, edition: 7, DOI
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Fast approximative methods for study of ligand transport and rational design of improved enzymes for biotechnologies
Biotechnology Advances, year: 2022, volume: 60, edition: November, DOI
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Non-psychotropic cannabinoids as inhibitors of TET1 protein
Bioorganic Chemistry, year: 2022, volume: 124, edition: July 2022, DOI
2021
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Computational design of enzymes for biotechnological applications
Biotechnology Advances, year: 2021, volume: 47, edition: March–April, DOI
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FireProt(DB): database of manually curated protein stability data
Nucleic acids research, year: 2021, volume: 49, edition: D1, DOI
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Genomic landscape of B-other acute lymphoblastic leukemia in an adult retrospective cohort with a focus on BCR-ABL1-like subtype
Acta Oncologica, year: 2021, volume: 60, edition: 6, DOI
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Hypermethylation of CD19 promoter enables antigen-negative escape to CART-19 in vivo and in vitro
Journal for ImmunoTherapy of Cancer, year: 2021, volume: 9, edition: 8, DOI
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Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond
International Journal of Molecular Sciences, year: 2021, volume: 22, edition: 2, DOI
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Multi-pathogen infections and Alzheimer's disease
Microbial Cell Factories, year: 2021, volume: 20, edition: 1, DOI
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Web-based tools for computational enzyme design
Current Opinion in Structural Biology, year: 2021, volume: 69, edition: August 2021, DOI