Project information

Prach v prostředí jako důležitá expoziční cesta člověka působení endokrinních disruptorů

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Project Identification
GA19-20479S
Project Period
1/2019 - 6/2022
Investor / Pogramme / Project type
Czech Science Foundation
MU Faculty or unit
Faculty of Science

Environmental exposure to endocrine disrupting chemicals (EDCs) is an important route of human exposure to these high priority substances. As people spend most of their time indoors, exposure through indoor environments is a relevant pathway for EDCs such as flame retardants, plasticizers and biocides. Indoor dust is a sink for many EDCs and its ingestion can result in possible risk to humans due to toxic effects from dust exposure. This project will address key research gaps linking concentrations of EDCs in dust with toxic effects by assessing the physical and chemical composition, bioaccessibility and in vitro toxicity of indoor dust samples covering a representative set of indoor environments. The composition of EDCs in dusts will be determined using state-of-the-art mass spectrometry to enable screening of ~200 individual EDCs. Bioaccessibility will be assessed using a novel passive sampling method linking with laboratory-based gut bioaccessibility tests. Toxicity will be evaluated using a wide range of in vitro toxicity tests on both the bulk dust and bioaccessible fraction, and mixture toxicity modelling will be used to link the toxicity and chemical profiles. Finally, drivers of toxicity will be assessed through effect-directed analysis, and the results from individual project elements will be linked to develop a conceptual model of dust exposure and toxicity.

Publications

Total number of publications: 5


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