Publication details

Endocrine disrupting potential of total and bioaccessible extracts of dust from seven different types of indoor environment

Investor logo
Investor logo
Investor logo
Investor logo
Authors

PINTO VIDAL Felipe Augusto NOVÁK Jiří JÍLKOVÁ Simona Rozárka RUSINA Tatsiana VRANA Branislav MELYMUK Lisa Emily HILSCHEROVÁ Klára

Year of publication 2024
Type Article in Periodical
Magazine / Source Journal of Hazardous Materials
MU Faculty or unit

Faculty of Science

Citation
Web https://www.sciencedirect.com/science/article/pii/S0304389424003571?via%3Dihub
Doi http://dx.doi.org/10.1016/j.jhazmat.2024.133778
Keywords Indoor dust; Bioaccessibility; Endocrine disrupting chemicals; Human risk assessment; In vitro
Attached files
Description exposure potential mostly limited to a few pollutant groups and indoor types. This study provides a comprehensive toxicological profile of chemical mixtures associated with dust from various types of indoor environments, namely cars, houses, prefabricated apartments, kindergartens, offices, public spaces, and schools. Organic extracts of two different polarities and bioaccessible extracts mimicking the gastrointestinal conditions were prepared from two different particle size fractions of dust. These extracts were tested on a battery of human cell -based bioassays to assess endocrine disrupting potentials. Furthermore, 155 chemicals from different pollutant groups were measured and their relevance for the bioactivity was determined using concentration addition modelling. The exhaustive and bioaccessible extracts of dust from the different microenvironments interfered with aryl hydrocarbon receptor, estrogen, androgen, glucocorticoid, and thyroid hormone (TH) receptor signalling, and with TH transport. Noteably, bioaccessible extracts from offices and public spaces showed higher estrogenic effects than the organic solvent extracts. 114 of the 155 targeted chemicals were detectable, but the observed bioactivity could be only marginally explained by the detected chemicals. Diverse toxicity patterns across different microenvironments that people inhabit throughout their lifetime indicate potential health and developmental risks, especially for children. Limited data on the endocrine disrupting potency of relevant chemical classes, especially those deployed as replacements for legacy contaminants, requires further study.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.

More info