Project information
Project information
Prozánětlivé působení LPS sinicového vodního květu z rekreačních nádrží České republiky
- Project Identification
- GA19-09980S
- Project Period
- 1/2019 - 12/2021
- Investor / Pogramme / Project type
-
Czech Science Foundation
- Standard Projects
- MU Faculty or unit
- Faculty of Science
- Cooperating Organization
-
The Academy of Sciences of the Czech Republic
- Responsible person RNDr. Lenka Švihálková Šindlerová, Ph.D.
The project will focus on the characterization of lipopolysaccharides (LPS) isolated from cyanobacterial water blooms collected from the Czech water reservoirs. Biological activity of the isolated LPS fractions will be investigated, and specifically their effects in the in vitro models of human immune, intestinal and skin epithelial cells will be studied, in order to evaluate their pro-inflammatory effects and potential to induce various adverse health outcomes, such as gastroenteritis and intestinal inflammation, skin irritations and contact dermatitis.
Publications
Total number of publications: 2
2024
-
Cyanobacterial bloom-associated lipopolysaccharides induce pro-inflammatory processes in keratinocytes in vitro
Environmental Toxicology and Pharmacology, year: 2024, volume: 105, edition: January 2024, DOI
2023
-
Cyanobacterial Harmful Bloom Lipopolysaccharides Induce Pro-Inflammatory Effects in Immune and Intestinal Epithelial Cells In Vitro
Toxins, year: 2023, volume: 15, edition: 3, DOI