Project information
Telomere dynamics in selected types of solid malignant diseases
- Project Identification
- GA301/99/0045
- Project Period
- 1/1999 - 1/2001
- Investor / Pogramme / Project type
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Czech Science Foundation
- Standard Projects
- MU Faculty or unit
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Faculty of Science
- Cooperating Organization
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Institute of Biophysics
- Responsible person prof. RNDr. Jiří Fajkus, CSc.
- Responsible person doc. RNDr. Lenka Fajkusová, CSc.
- Responsible person prof. MUDr. Rostislav Vyzula, CSc.
Telomerase, a nucleoprotein enzyme complex, plays a crucial role in the development of cellular immortality and carcinogenesis. The project is focused on using activity and expression of telomerase in molecular diagnostics of cancer. The work on the pro ject will result in providing data on telomere dynamics in cancer tissue samples, as well as in optimising diagnostic methods and their introduction in oncolgy practice.
Publications
Total number of publications: 22
2000
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Telomerase Activity and Expresion and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias
Blood Cells, Molecules and Diseases, year: 2000, volume: 26, edition: 5
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Telomerase activity and expression in the course of treatment of acute childhood leukemias
Miami Nature Biotechnology Short Reporřts, Volume 11m, Advances in Gene Technology: DNA, RNA and CANCER, year: 2000
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Telomerase Activity,Expression and Telomere in situ Analysis in the Course of Treatment of Childhood Leukemias
J.Biomol. Struct. Dyn., year: 2000, volume: 17, edition: 6
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The use of interferon alpha in therapy of chronic immune thrombocytopenic purpura in children
Europediatrics Abstract Book, year: 2000
1999
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An in Situ Study of Variant Telomeric Repeats in Human Chromosomes
Genomics, year: 1999, volume: 58, edition: 2
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Cytomegalovirová infekce u dětí se zhoubným nádorovým onemocněním: od sérologie k průkazu virové DNA
Klinicka onkologie, year: 1999, volume: 12, edition: 4
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In situ studies of human telomeres
Abstracts of the Second European Cytogenetics Conference, year: 1999
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Molecular Cytogenetics Investigation of The Telomers in a Case of Philadelphia Positive B-ALL with a Single Telomere Expansion
Neoplasia, year: 1999, volume: 1, edition: 6
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Sledování aktivity telomerázy v průběhu léčby dětských leukémií
Sborník abstrakt, year: 1999
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Telomeráza - aktivita a diagnostické použití u leukémií a solidních tumorů
Abstrakta 43. Studentské vědecké konference, year: 1999