Project information
Bacteriocins of the family Enterobacteriaceae: incidence, new types and molecular biology
- Project Identification
- GA310/98/0083
- Project Period
- 1/1998 - 1/2000
- Investor / Pogramme / Project type
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Czech Science Foundation
- Standard Projects
- MU Faculty or unit
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Faculty of Medicine
- prof. MUDr. Jan Šmarda, DrSc.
- Cooperating Organization
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Institute of Microbiology of the ASCR, v. v. i.
- Responsible person RNDr. Oldřich Benada, CSc.
The project involves 6 topics which have been opened to research by applicants experiments in the last years: 1) research on the incidence of bacteriocinogeny among strains of the newly acknowledged species of Escherichia and subspecies of Klebsiella. 2) for a closer comprehension of successive steps in the action of colicins E1-E9, research on the relation between their binding on susceptible bacteria and their inhibitive action. 3) investigation into physico-chemical, biological and molecular paramete rs of a new type of colicin, colicin 4. 4) for comparative analysis of binding of colicins E1-E3 onto their respective epitopes in the receptor protein BtuB, quantification of effects of its modifications with specific amino acid reagents. 5) investigati on of the incidence of colicinogeny among E. coli strains present in a healthy colon and in a colon with cancer. 6) as, in some genera, a production of "corpuscular bacteriocins" was found by applicant, studies of their ultrastructure and screening of fu
Publications
Total number of publications: 10
2000
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Bactericidal phage tail-like particules of Budvicia and Pragia.
Proceedings of the 12th European Congress on Electron Microscopy, year: 2000
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Binding domaines of colicin E1, E2 and E3 in the receptor protein BtuB of Escherichia coli
Folia microbiologica, year: 2000, volume: 45, edition: 5
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Incidence kolicinogenie mezi kmeny rodu Escherichia humánního původu
Zprávy Centra epidemiologie a mikrobiologie (SZÚ), year: 2000, volume: 9, edition: 2
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Koliciny a jejich účinek na eukaryontní (normální versus nádorové) buňky.
Biochemie a molekulární biologie na prahu nového tisíciletí (IV. Pracovní setkání biochemiků a molekulárních biologů), year: 2000
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Koliciny a jejich účinek na nádorové buňky.
Tomáškovy dny 2000, year: 2000
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Koliciny obecně a nový kolicin U zvláště.
Biochemie a molekulární biologie na prahu nového tisíciletí, year: 2000
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Koliciny rodu Shigella
Biochemie a molekulární biologie na prahu nového tisíciletí, year: 2000
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Srovnání působení kolicinů E1 a E2 na bakteriální buňky a jejich sféroplasty
Sborník příspěvků V. Pracovního setkání biochemiků a molekulárních biologů, year: 2000
1999
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Colicins of the genus Shigella
Scripta medica, year: 1999, volume: 72, edition: 8
1997
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Koliciny- letální proteiny z čeledi Entobacreriaceae
Biologické listy, year: 1997, volume: 62, edition: 2