Project information
DIANA panel for testing of selectivity of inhibitors of clinically relevant protein kinases and its application in the drug discovery market. Preclinical development of new inhibitors of CDK11 - key enzyme for growth of cancer cells.
- Project Identification
- FW03010138
- Project Period
- 1/2021 - 12/2024
- Investor / Pogramme / Project type
-
Technology Agency of the Czech Republic
- TREND
- Subprograms 1 Technology leaders
- MU Faculty or unit
- Central European Institute of Technology
- Other MU Faculty/Unit
- Faculty of Science
- Cooperating Organization
-
DIANA Biotechnologies, s.r.o.
- Responsible person Mgr. Václav Navrátil, Ph.D.
Projekt má dva hlavní cíle:
1) Vyvinout metodu založenou na technologii DIANA pro měření afinity a selektivity inhibitorů CDK a dalších klinicky relevantních kináz.
2) Nalézt nové selektivní inhibitory CDK11 a provést jejich preklinický vývoj s ohledem na jejich potenciál pro léčbu onkologických indikací.
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