The project aims to contribute to the understanding of renoprotective effect of gliflozins, a new class of antidiabetic drugs. Two approaches are planned: (1) an observational study of T2DM patients who are eligible for gliflozin treatment on top of the current antidiabetic treatment and (2) in vitro analysis of human-derived proximal tubular epithelial cells. Specific molecular pathways studied include dicarbonyl stress and cell death pathways.

Sustainable Development Goals

Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.