Retinal organoids as a tool for investigating embryonal diabetic retinopathy.
- Project Identification
- Project Period
- 1/2023 - 12/2023
- Investor / Pogramme / Project type
- MU Faculty or unit
Faculty of Medicine
- Mgr. Tomáš Bárta, Ph.D.
- Canan Çeliker, MSc
- Bc. Samuel Hollý
Diabetes has a profound impact on the retina and affects the blood–retinal barrier, capillaries and alterations in the neuronal and glial cells of the retina. Currently little is known about the effects of hyperglycaemia on retinal cell types during the development of the embryonic human retina. Additionally there are no established tools for modelling DR in humans, especially for embryonic hyperglycaemia-induced retinopathy.
In this project we will use retinal organoids derived from induced pluripotent stem (hiPS) cells as a model to closely investigate the effects of hyperglycaemia on human retinal development.