Role of Caveolin-1 in the biogenesis of phosphatidylserine-positive extracellular vesicles
- Project Identification
- Project Period
- 1/2023 - 12/2023
- Investor / Pogramme / Project type
- MU Faculty or unit
- Faculty of Medicine
This project focuses on the novel functions of Caveolin-1 (Cav-1) and their possible oncogenic properties. Earlier studies implicated Cav-1 in endocytosis, signaling and lipid disorders. However, the recent studies have revealed its novel role in the biogenesis of extracellular vesicles (EVs) and also clarified its relevance in cancer.
In this project, we aimed to explore the effect of Cav-1 on cargo sorting into EVs and resulting protein composition of EVs produced by prostate cancer cells (prostasomes) and the effect of these prostasomes on the process of malignant transformation. We also introduce the hypothesis that Cav-1 can maintain the protumorigenic composition of EVs cargo and changes the character of EVs involved in cell-cell communication, which makes the study attractive for anticancer therapy.
The results will be involved in the project proposal at an external grant agency.
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