Invasive yeast infections, particularly those caused by Candida species, are a significant cause of morbidity and mortality in hospitalized and immunocompromised patients. This project aims to advance the surveillance of Candida and emerging yeast pathogens using long-read genomics to study resistance and epidemiology. The increasing prevalence of non-albicans species and multidrug-resistant strains, such as Candida auris, Candida parapsilosis, and Nakaseomyces glabratus, poses a severe challenge to clinical management. By employing whole-genome sequencing and high-throughput molecular approaches, this research will uncover genetic determinants of antifungal resistance and track the spread of resistant clones. The project will establish a robust molecular epidemiology framework for invasive candidiasis, enabling better surveillance, antifungal stewardship, and improved patient outcomes. The integration of up-to-date bioinformatics tools and interactive database will facilitate real-time resistance tracking and clinical decision support, addressing the urgent need for standardized monitoring protocols and enhanced infection control measures.

Sustainable Development Goals

Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.