Project information
ECPAS-Mediated Proteasome Remodeling as a Mechanism of Resistance to Proteasome Inhibition in Multiple Myeloma
- Project Identification
- GA26-21116S
- Project Period
- 1/2026 - 12/2028
- Investor / Pogramme / Project type
-
Czech Science Foundation
- Standard Projects
- MU Faculty or unit
- Faculty of Medicine
This project aims to characterize proteasome composition, activity, and localization in bortezomib-naïve and resistant multiple myeloma models, including those with reduced ECPAS, PSMD5, and PSME1 levels, to define their roles in proteasome dynamics and resistance to proteasome inhibition.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
