Project information
VDAC as a Mitochondrial Nucleic Acid Sensor: Structural and Functional Implications

Mitochondria are often called the powerhouses of the cell, but their role extends far beyond energy production. They regulate metabolism, cell survival, immunity, and even gene expression, making them essential for the cell's overall health. Recent research has linked mitochondrial dysfunction to diseases such as Parkinson’s disease, neurodegeneration, systemic lupus erythematosus, and cancer, highlighting mitochondria as potential therapeutic targets. The voltage-dependent anion channel 1 (VDAC1), a protein in the outer mitochondrial membrane, is associated with mitochondrial permeability transition and may facilitate the release of mtDNA in response to cellular stress, triggering immune responses. A specific noncoding region of mitochondrial DNA, the D-loop, could serve as a key binding partner in this process. Therefore, understanding how VDAC1 interacts with the D-loop and its role in immune activation could offer new insights into disease mechanisms and pave the way for novel treatments.