Project information

Verification of DNA Profile as a Prognostic Factor and Monitoring Chemotherapy-Induced Clonal Evolution of Squamous Cell Carcinomas in Waldayer's Circuit by Flo

Project Identification
NC4641
Project Period
1/1998 - 1/2000
Investor / Pogramme / Project type
Ministry of Health of the CR
MU Faculty or unit
Faculty of Medicine
Cooperating Organization
St. Anne's University Hospital Brno

A retrospective study of a set of 90 patients with squamous cells carcinoma of Waldayer´s circuit treated with neoadjuvant chemotherapy,surgery,irradiation and adjuvant chemotherapy. A paraffine block of tumor biopsy taken before and after chemotherapy is at disposal. Monitoring the changes of the DNA profiel by means of flow cytometry should reveal the suitability of this therapeutical algorithm as well as verify the possibility of applying the DNA profile as a tumor marker in the ENT clinical practice.

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