Publication details
Complete genome sequence of Treponema pallidum strain DAL-1
| Authors | |
|---|---|
| Year of publication | 2012 |
| Type | Article in Periodical |
| Magazine / Source | Standards in Genomic Sciences |
| MU Faculty or unit | |
| Citation | |
| Web | http://standardsingenomics.org/index.php/sigen/article/view/sigs.2615838/784 |
| Doi | http://dx.doi.org/10.4056/sigs.2615838 |
| Field | Genetics and molecular biology |
| Keywords | Spirochaetaceae; Treponema pallidum; syphilis |
| Description | Treponema pallidum strain DAL-1 is a human uncultivable pathogen causing the sexually transmitted disease syphilis. Strain DAL-1 was isolated from the amniotic fluid of a pregnant woman in the secondary stage of syphilis. Here we describe the 1,139,971 bp long genome of T. pallidum strain DAL-1 which was sequenced using two independent sequencing methods (454 pyrosequencing and Illumina). In rabbits, strain DAL-1 replicated better than the T. pallidum strain Nichols. The comparison of the complete DAL-1 genome sequence with the Nichols sequence revealed a list of genetic differences that are potentially responsible for the increased rabbit virulence of the DAL-1 strain. |
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