Publication details

Úloha chromozomových aberací v patogenezi monoklonální gamapatie nejasného významu

Title in English The role of chromosomal aberrations in pathogenesis of monoclonal gammopathy of undetermined significance
Authors

MIKULÁŠOVÁ Aneta KUGLÍK Petr SMETANA Jan GREŠLIKOVÁ Henrieta ŘÍHOVÁ Lucie KLINCOVÁ Mária HÁJEK Roman

Year of publication 2012
Type Article in Periodical
Magazine / Source Klinická biochemie a metabolismus
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords MGUS; monoclonal gammopathies; molecular cytogenetics; chromosomal abnormalities
Attached files
Description Monoclonal gammopathy of undetermined significance (MGUS) is a precancerosis permanently associated with higher risk of progression into multiple myeloma (MM). One of the goals of the current molecular cytogenetic approach is identification of suitable genetic markers which distinguish high-risk MGUS patients. Cytogenetic analysis showed that the same chromosomal abnormalities found in MM, both structural and numerical, are already found in precancerous plasma cells. There are especially primary IGH (14q32) translocations, in most cases with chromosomal loci including genes CCND1 (11q13), FGFR3 (4p16) and MAF (16q23), as well as trisomies of chromosomes 3, 5, 7, 9 and monosomy of chromosome 13. However, specific chromosomal changes that could reliably predict the risk of transition from precancerosis into malignancy have not been identified. This paper summarizes the current knowledge about significance of chromosomal abnormalities in MGUS pathogenesis and in transformation from this precancerosis into tumor.
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