Publication details
Molecular dynamics simulations of G-DNA and perspectives on the simulation of nucleic acid structures
| Authors | |
|---|---|
| Year of publication | 2012 |
| Type | Article in Periodical |
| Magazine / Source | Methods |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.sciencedirect.com/science/article/pii/S1046202312000941 |
| Doi | http://dx.doi.org/10.1016/j.ymeth.2012.04.005 |
| Field | Biophysics |
| Keywords | Molecular dynamics simulations; Guanine quadruplex; DNA ligand binding; Force field limitations; Force field development |
| Attached files | |
| Description | The article reviews the application of biomolecular simulation methods to understand the structure, dynamics and interactions of nucleic acids with a focus on explicit solvent molecular dynamics simulations of guanine quadruplex (G-DNA and G-RNA) molecules. While primarily dealing with these exciting and highly relevant four-stranded systems, where recent and past simulations have provided several interesting results and novel insight into G-DNA structure, the review provides some general perspectives on the applicability of the simulation techniques to nucleic acids. (C) 2012 Elsevier Inc. All rights reserved. |
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