Publication details

VLIV DLOUHODOBÉ APLIKACE HALOPERIDOLU NA ELEKTROGRAM IZOLOVANÉHO SRDCE A EXPRESI SIGMA 1 A IP3 RECEPTORŮ U MORČETE

Title in English EFFECT OF LONG-TERM APPLICATION OF HALOPERIDOL ON ELECTROGRAM OF ISOLATED HEART AND EXPRESSION OF SIGMA 1 AND IP3 RECEPTORS IN GUINEA PIG
Authors

STRAČINA Tibor NOVÁKOVÁ Marie

Year of publication 2012
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description Our work was focused on effect of long-term application of haloperidol on electrogram of isolated heart and expression of sigma 1 and IP3 receptors in guinea pig. We showed that expression of sigma 1 receptors was increased in atria of the heart after long-term application of haloperidol. Withal, the spontaneous heart rate was decreased, the QT interval of electrogram was extended and incidence of supraventricular extrasystoles was increased.
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