Publication details

Získaná hemofilie A

Title in English Acquired haemophilia A
Authors

SMEJKAL Petr BULIKOVÁ Alena CHLUPOVÁ Gabriela ZAVŘELOVÁ Jiřina

Year of publication 2012
Type Article in Periodical
Magazine / Source Vnitřní lékařství
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords Acquired factor VIII inhibitor; Acquired haemophilia A; Bleeding; Immunosuppression; Treatment
Description Acquired haemophilia A is a rare auto-immune disease caused by an inhibitory antibody to factor VIII. Patients with this disorder are at high risk of severe bleeding until the inhibitor has been eradicated. Management of this disorder consists in rapid accurate diagnosis, control of bleeding and eradication of the inhibitor by immunosuppression. The cessation of bleeding is based mainly on recombinant factor VIIa and activated prothrombin complex concentrate which are approximately equally efficacious. Immunosuppression is still based on steroids alone or with combination with cyclopfosphamide which may result in a higher rate of remission. New drugs as rituximab or cyclosporine A are the second line option. In case of life-threatening bleeding immunoadsorption and high dose of factor VIII could be advantageous.

You are running an old browser version. We recommend updating your browser to its latest version.

More info