Publication details

Chirurgická prevence karcinomu prsu u pacientek s dědičným rizikem

Title in English Surgical Prevention of Breast Carcinoma in Patients with Hereditary Risk
Authors

DRAŽAN Luboš VESELÝ Jiří HÝŽA Petr KUBEK Tomáš FORETOVÁ Lenka COUFAL Oldřich

Year of publication 2012
Type Article in Periodical
Magazine / Source Klinická onkologie
MU Faculty or unit

Faculty of Medicine

Citation
Web http://www.linkos.cz/files/klinicka-onkologie/172/4072.pdf
Field Surgery incl. transplantology
Keywords prophylactic mastectomy – BRCA – immediate breast reconstruction
Description Background: Women with BRCA1 gene mutation have 85% risk of breast cancer; the risk for BRCA2 carriers is 45%. The aim of the study was to verify if prophylactic mastectomy with immediate breast reconstruction can prevent breast cancer in BRCA positive patients. Material: There were 100 BRCA positive women in which prophylactic mastectomy with immediate reconstruction, 75 dieps, 25 with implants, performed in period 2000–2011. Group A was composed of healthy, non-affected 41 patients, group B of 59 patients in remission after breast cancer treatment. These groups were compared to group C that consisted of 219 healthy carriers of BRCA1/2, non-operated, from registry of genetic department of the Masaryk Memorial Cancer in Brno, from 2000–2011. Method: Follow-up for oncology status was done in September 2011 for all 3 groups. Results: Average follow-up of 21 months revealed that in group A there was no breast cancer, in group B 4 patients died and 2 had treatment for metastases. In group C, there were 16 new cases of breast cancer. Conclusion: Bilateral prophylactic mastectomy with immediate reconstruction can be an effective way in breast cancer prevention in healthy carriers of BRCA1/2 mutation. In BRCA positive patients treated for breast cancer, the effect of prophylactic mastectomy is unclear. Their survival is more influenced by their previous disease than by a new tumor in the breast.

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