Publication details

1q21 amplification with additional genetic abnormalities but not isolated 1q21 gain is a negative prognostic factor in newly diagnosed patients with multiple myeloma treated with thalidomide-based regimens

Authors

GRZASKO Norbert HUS Marek CHOCHOLSKA Sylwia PLUTA Andrzej HÁJEK Roman DMOSZYNSKA Anna

Year of publication 2012
Type Article in Periodical
Magazine / Source Leukemia & lymphoma
MU Faculty or unit

Faculty of Medicine

Citation
Web http://informahealthcare.com/doi/abs/10.3109/10428194.2012.684349
Doi http://dx.doi.org/10.3109/10428194.2012.684349
Field Oncology and hematology
Keywords In-Situ Hybridization; Expression; Chromosome-1; Survival; Model
Attached files
Description In this study we assessed the prognostic value of amp(1q21) alone and in combination with del(17p13), del(13q14) and t(4,14)(p16;q32) detected by fl uorescence in situ hybridization(FISH) in newly diagnosed patients with MM treated with thalidomide-based induction regimens. Th e primary endpoints were response rate after fi rst-line therapy, PFS and OS.

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