Publication details

Expression of FGF19 in Human Embryonic Stem Cells

Authors

KREJČÍ Pavel KUNOVÁ Michaela KUBÍKOVÁ Iva TRANTÍREK Lukáš KOZUBÍK Alois DVOŘÁK Petr

Year of publication 2013
Type Article in Periodical
Magazine / Source STEM CELLS
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1002/stem.1493
Field Genetics and molecular biology
Keywords Cell signaling; Embryonic stem cells; FGF19; Fibroblast growth factor; Expression
Description In human embryonic stem cells, continuous stimulation with fibroplast growthfactor 2 is required for self-renewal. inhibition of FGF2 signaling results in rapid differentiation, further underscoring the importance of FGF system in maintenance of hESC undifferentiated state. In addition to FGF2, human FGF family contains 17 members which presence in hESC remains unclear, with exception of FGF4.
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