Publication details
Úloha hypoxie v regulaci exprese ABC-transportérů asociovaných s MDR u (embryonálních) kmenových buněk
| Title in English | The role of hypoxia in expression of MDR-associated ABC transporters in (embryonic stem) cells |
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| Authors | |
| Year of publication | 2012 |
| Type | Article in Proceedings |
| Conference | Konference mladých vědeckých pracovníků s mezinárodní účastí 2012 na FVL VFU Brno |
| MU Faculty or unit | |
| Citation | |
| Web | http://cit.vfu.cz/fyziolmed/images/stories/files/KMVP_sbornik_web.pdf |
| Field | Physiology |
| Keywords | ABC-transporter stem cells hypoxia |
| Description | High level of ATP binding cassette (ABC) transporters expression is charakteristic for stem cells and various types of cancer stem cells. For multidrug resistance (MDR) are responsible ABC B1/P-glycoprotein/MDR1, ABC C1/ multidrug resistance associated protein 1 (MRP1), and ABC G2/BCRP(1). These transporters protect stem cells against toxic substances, either endogenous or exogenous origin. Moreover they also have an important role in regulating the differentiation and proliferation of diverse cell types. |
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