Publication details

Epigenetic aspects of HP1 exchange kinetics in apoptotic chromatin

Authors

LEGARTOVÁ Soňa JUGOVÁ Alžběta STIXOVÁ Lenka KOZUBEK Stanislav FOJTOVÁ Miloslava ZDRÁHAL Zbyněk LOCHMANOVÁ Gabriela BÁRTOVÁ Eva

Type Article in Periodical
Magazine / Source Biochemistry & Molecular Biology
MU Faculty or unit

Central European Institute of Technology

Citation
Doi http://dx.doi.org/10.1016/j.biochi.2012.09.027
Field Genetics and molecular biology
Keywords Apoptosis; Histones; HP1; Epigenetics; Chromatin
Description Apoptotic bodies are the most condensed form of chromatin. In general, chromatin structure and function are mostly dictated by histone post-translational modifications.HP1 mobility in apoptotic cells appeared to be unique because limited exchange after photobleaching was observed for other epigenetically important proteins, including GFP-JMJD2b histone demethylase (similar to 10% fluorescence recovery) or Polycomb group-related GFP-BMI1 protein (similar to 20% fluorescence recovery). These findings imply a novel fact that only certain subset of proteins in apoptotic bodies is dynamic.
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