Publication details

Human Pluripotent Stem Cell-Derived Cardiomyocytes as Research and Therapeutic Tools

Authors

AĆIMOVIĆ Ivana VILOTIĆ Aleksandra PEŠL Martin LACAMPAGNE Alain DVOŘÁK Petr ROTREKL Vladimír MELI Albano

Year of publication 2014
Type Article in Periodical
Magazine / Source BioMed Research International
MU Faculty or unit

Faculty of Medicine

Citation
Web http://downloads.hindawi.com/journals/bmri/2014/512831.pdf
Doi http://dx.doi.org/10.1155/2014/512831
Field Genetics and molecular biology
Keywords human pluripotent stem cell; differentiation; cardiomyocyte; calcium; disease model
Attached files
Description Human pluripotent stem cells (hPSCs), namely, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), with their ability of indefinite self-renewal and capability to differentiate into cell types derivatives of all three germlayers, represent a powerful research tool in developmental biology, for drug screening, disease modelling, and potentially cell replacement therapy. Efficient differentiation protocols that would result in the cell type of our interest are needed for maximal exploitation of these cells. In the present work, we aim at focusing on the protocols for differentiation of hPSCs into functional cardiomyocytes in vitro as well as achievements in the heart disease modelling and drug testing on the patient-specific iPSC-derived cardiomyocytes (iPSC-CMs).
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