Publication details
Patogeneze kancerogenity etanolu u karcinomů hlavy a krku
| Title in English | Patogenesis of ethanol cancerogenity in head and neck carcinomas |
|---|---|
| Authors | |
| Year of publication | 2015 |
| Type | Article in Periodical |
| Magazine / Source | Onkologie |
| MU Faculty or unit | |
| Citation | |
| Field | ORL, ophthalmology, stomatology |
| Keywords | head and neck carcinomas; ethanol; acetaldehyde; alcohol dehydrogenase; aldehyde dehydrogenase; estrogens; androgens |
| Description | This article summarizes mechanisms through which ethanol promotes the genesis and growth of carcinomas of an upper aerodigestive tract. Ethanol plays a role in cancerogenesis as a cocancerogen because it facilitates penetration of other cancerogens to cells. However, ethanol also represents a direct cancerogen, because the cancerogenic acetaldehyde is formed of it. Ethanol can also promote the tumor growth through immunosupression or hormonal disturbances. |