Publication details
The impact of thyroid hormone replacement therapy on left ventricular diastolic function in patients with subclinical hypothyroidism
| Authors | |
|---|---|
| Year of publication | 2016 |
| Type | Article in Periodical |
| Magazine / Source | Journal of Endocrinological Investigation |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.1007/s40618-015-0262-2 |
| Field | Other specializations of internal medicine |
| Keywords | Subclinical hypothyroidism; Echocardiography; Left ventricular diastolic function; Heart failure |
| Description | Objective Subclinical hypothyroidism (SH) is associated with a moderately elevated risk of heart failure events among older adults. The objective of our prospective study was to assess the impact of thyroid hormone replacement therapy (HRT) with low doses of l-thyroxine (6.25-25 mu g/day) on left ventricular diastolic function in patients with SH. Materials and methods 33 patients with SH and 25 healthy controls were involved. All participants underwent standard echocardiography and Doppler imaging at baseline and, the patient group, also after a course of HRT. Results At baseline, patients with SH showed significantly lower E (0.79 +/- 0.22 vs. 0.93 +/- 0.19, p < 0.001), E/A ratio (1.19 +/- 0.29 vs. 1.31 +/- 0.25, p < 0.003), and higher intraventricular septum thickness (IVST) (0.99 +/- 0.14 vs. 0.89 +/- 0.18, p < 0.001) in comparison with healthy controls. After 6 months of therapy, the E/A ratio underwent significant increase (1.28 +/- 0.21 vs. 1.19 +/- 0.29, p < 0.001), while the IVS displayed a robust reduction (0.92 +/- 0.16 vs. 0.99 +/- 0.14, p < 0.001). Conclusions HRT with low-dosed l-thyroxine may improve left ventricular diastolic function in patients with SH. |