Uric acid contributes to the faster progression of diabetic kidney disease and higher incidence of major cardiovascular event in type 2 diabetic patients

• Authors: PÁCAL Lukáš; BARTÁKOVÁ Vendula; KURICOVÁ Katarína; NOVÁ Zuzana; DVOŘÁKOVÁ Veronika; ŠVRČKOVÁ Martina; MALÚŠKOVÁ Denisa; ŘEHOŘOVÁ Jitka; SVOJANOVSKÝ Jan; OLŠOVSKÝ Jindřich; BĚLOBRÁDKOVÁ Jana; KRUSOVÁ Darja; KAŇKOVÁ Kateřina
• Year of publication: 2015
• Type: Conference abstract
• Description: Recent evidence suggests that increased serum uric acid (SUA) is associated with increased risk of diabetic kidney disease (DKD) development in patients with type 1 diabetes. Data on the role of SUA in the progression of DKD in type 2 diabetes (T2DM) are lacking. Polymorphisms in genes encoding for uric acid transporters in the kidney (SLC2A9, ABCG2) and gut (ABCG2) affect SUA and were associated with hyperuricaemia and gout but were not studied with respect to DKD yet. The aims of the study were to assess (i) the prognostic value of baseline SUA and (ii) variability in selected genes involved in the regulation of uric acid metabolism for DKD progression in T2DM.

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