Publication details

Stress, catecholaminergic system and cancer



Year of publication 2016
Type Article in Periodical
Magazine / Source Stress
MU Faculty or unit

Faculty of Medicine

Field Physiology
Keywords Adrenergic receptors; beta-blockers; catecholamines; dopamine; epinephrine; norepinephrine; stress; tumor
Description Stress as a modern civilization factor significantly affects our lives. While acute stress might have a positive effect on the organism, chronic stress is usually detrimental and might lead to serious health complications. It is known that stress induced by the physical environment (temperature-induced cold stress) can significantly impair the efficacy of cytotoxic chemotherapies and the anti-tumor immune response. On the other hand, epidemiological evidence has shown that patients taking drugs known as beta-adrenergic antagonists ("beta-blockers"), which are commonly prescribed to treat arrhythmia, hypertension, and anxiety, have significantly lower rates of several cancers. In this review, we summarize the current knowledge about catecholamines as important stress hormones in tumorigenesis and discuss the use of beta-blockers as the potential therapeutic agents.
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