Publication details

Emergence of the First Catalytic Oligonucleotides in a Formamide-Based Origin Scenario

Authors

ŠPONEROVÁ Judit ŠPONER Jiří NOVÁKOVÁ Olga BRABEC Viktor ŠEDO Ondrej ZDRÁHAL Zbyněk COSTANZO Giovanna PINO Samanta SALADINO Raffaele DI MAURO Ernesto

Type Article in Periodical
Magazine / Source Chemistry - A European Journal
MU Faculty or unit

Central European Institute of Technology

Citation
Web http://onlinelibrary.wiley.com/doi/10.1002/chem.201503906/full
Doi http://dx.doi.org/10.1002/chem.201503906
Field Physical chemistry and theoretical chemistry
Keywords formamide; nucleobases; nucleotides; origin of life; RNA
Description 50years after the historical Miller-Urey experiment, the formamide-based scenario is perhaps the most powerful concurrent hypothesis for the origin of life on our planet besides the traditional HCN-based concept. The information accumulated during the last 15years in this topic is astonishingly growing and nowadays the formamide-based model represents one of the most complete and coherent pathways leading from simple prebiotic precursors up to the first catalytically active RNA molecules. In this work, we overview the major events of this long pathway that have emerged from recent experimental and theoretical studies, mainly concentrating on the mechanistic, methodological, and structural aspects of this research.
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